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Clusters for high-value crops are ubiquitous in China and in African countries. Drawing from three case studies (potato cluster in China, medicinal and aromatic cluster in Egypt, and dates cluster in Tunisia), this chapter discusses the major challenges facing cluster development and the roles of different agents (e.g. entrepreneurs, business associations, and local governments). Cluster development involves supply-side or demand-side bottlenecks along the way, which are beyond the capacity of individual enterprises.